The House Committee on Business Affairs & Labor considers matters concerning the regulation of professions and occupations, property and casualty insurance, unemployment insurance, health insurance, workers' compensation insurance, economic development, banks and financial institutions, real estate, labor, and technology. In addition, the committee has legislative oversight responsibility for the Department of Labor and Employment, the Department of Personnel and Administration, the Department of Regulatory Agencies, and the Office of Economic Development and International Trade.

The House Agriculture, Livestock, & Water Committee generally considers matters concerning water, agriculture, wildlife, and recreation.  In addition, the committee has legislative oversight responsibility for the departments of Agriculture and Natural Resources.

The House Public & Behavioral Health & Human Services Committee considers matters concerning state health care programs and social services.  The committee also has legislative oversight responsibility for the Department of Health Care Policy and Financing and the Department of Human Services.

The Capitol Building Advisory Committee is comprised of legislative and non-legislative members and is charged with reviewing and advising for the protection of the Capitol building's historic character, including its art, memorials, furniture, and architectural fixtures.

The Senate Judiciary Committee considers matters concerning civil and criminal proceedings, courts, judges, civil liberties, Colorado's constitution and statutes, the state's correctional system and prison facilities, homeland security, and juvenile justice.  In addition, the committee has legislative oversight responsibility for the Department of Corrections, the Department of Public Safety, the Department of Law, and the Judicial Branch.

The Senate Transportation & Energy Committee considers matters concerning motor vehicle law, traffic regulation, transportation funding, public infrastructure, other subject areas related to the state transportation system, and energy development and regulation.  In addition, the committee has legislative oversight responsibility for the Department of Transportation, the Colorado Energy Office, the Public Utilities Commission, and the Colorado Oil and Gas Conservation Commission.

The Senate Finance Committee generally considers matters related to a broad range of public finance proposals including legislation that affects the state's revenue and tax structure.  In addition, the committee has legislative oversight responsibility for the Public Employees' Retirement Association, Department of Revenue, State Treasury, and the Office of State Planning and Budgeting.